Association Between SARS-CoV-2 RNAemia and Postacute Sequelae of COVID-19

Nikhil Ram-Mohan; David Kim; Angela J Rogers; Catherine A Blish; Kari C Nadeau; Andra L Blomkalns; Samuel Yang

doi:10.1093/ofid/ofab646

Association Between SARS-CoV-2 RNAemia and Postacute Sequelae of COVID-19

Open Forum Infect Dis. 2021 Dec 25;9(2):ofab646. doi: 10.1093/ofid/ofab646. eCollection 2022 Feb.

Authors

Nikhil Ram-Mohan¹, David Kim¹, Angela J Rogers², Catherine A Blish³, Kari C Nadeau², Andra L Blomkalns¹, Samuel Yang¹

Affiliations

¹ Department of Emergency Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
² Department of Medicine-Pulmonary, Allergy & Critical Care Medicine, Stanford University School of Medicine, Palo Alto, California, USA.
³ Department of Medicine/Infectious Diseases, Stanford University School of Medicine, Palo Alto, California, USA.

Abstract

Determinants of Post-Acute Sequelae of COVID-19 are not known. Here we show that 83.3% of patients with viral RNA in blood (RNAemia) at presentation were symptomatic in the post-acute phase. RNAemia at presentation successfully predicted PASC, independent of patient demographics, worst disease severity, and length of symptoms.

Keywords: Long COVID; PASC; RNAemia; SARS-CoV-2.

Abstract

Grants and funding