Development and validation of a nomogram for primary duodenal carcinoma: a multicenter, population-based study

Future Oncol. 2022 Mar;18(10):1245-1258. doi: 10.2217/fon-2021-0622. Epub 2022 Feb 4.

Abstract

Aim: This study aimed to develop a predictive model for patients with duodenal carcinoma. Methods: Duodenal carcinoma patients from the Surveillance, Epidemiology, and End Results database (2010-2015) and the First Affiliated Hospital of Nanchang University (2010-2021) were enrolled. A nomogram was constructed according to least absolute shrinkage and selection operator regression analysis, the Akaike information criterion approach and Cox regression analysis. Results: Five independent prognostic factors were significantly associated with the prognosis of the duodenal carcinoma patients. A nomogram was constructed with a C-index in the training and validation cohorts of 0.671 (95% CI: 0.578-0.716) and 0.662 (95% CI: 0.529-0.773), respectively. Conclusion: The established nomogram model provided visualization of the risk of each prognostic factor.

Keywords: Surveillance Epidemiology and End Results; nomogram; primary duodenal carcinoma; prognosis; survival.

Publication types

  • Multicenter Study
  • Validation Study

MeSH terms

  • China / epidemiology
  • Duodenal Neoplasms / diagnosis*
  • Duodenal Neoplasms / mortality*
  • Duodenal Neoplasms / pathology
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Nomograms*
  • Prognosis
  • Risk Assessment / methods
  • SEER Program
  • United States / epidemiology