Associations of PM_2.5 exposure with blood glucose impairment in early pregnancy and gestational diabetes mellitus

Exposure to fine particulate matter (PM_2.5) during pregnancy has been linked to the risk of gestational diabetes mellitus (GDM), while conclusions are inconsistent. In this study we aimed to estimate the effects of prenatal PM_2.5 exposure with blood glucose in early pregnancy and the GDM risk. Participants were recruited from the SH-IPMCH-BTH cohort (n = 41,929), a study of air pollution and birth outcome. All participants provided serum samples for analyses of fasting blood glucose (FBG) and HbA1c during early pregnancy. GDM was diagnosed using an oral glucose tolerance test (OGTT) with the time interval of 1 h. Prenatal exposure to PM_2.5 was estimated using gap-filled satellite exposure assessments in Shanghai, China. Both FBG and HbA1c levels were significantly and positively associated with PM_2.5 exposure during early pregnancy. A 10 μg/m³ increase of PM_2.5 exposure from early to middle pregnancy was associated with the risk of GDM (first trimester OR=1.09, 95% CI: 1.02, 1.16; second trimester OR=1.09, 95% CI: 1.03, 1.16; first two trimester OR=1.15, 95%CI: 1.04, 1.28). The combined effects were greater among elevated FBG and HbA1c women with higher PM_2.5 exposure in middle trimester (P for interaction=0.037 and 0.001, respectively). This study found that exposure to PM_2.5 exposure in the 1^st and 2^nd trimesters was related to GDM. FBG and HbA1c played roles in the relationship between PM_2.5 exposure in the 2^nd trimester and GDM.