Abstract
The serological response to treponemal infections in men before and after specific treatment is analyzed. From the described observations several consequences and possibilities for a specific immunological diagnosis are discussed. In particular, it is shown that early diagnosis of syphilis in need of treatment can be achieved by demonstration of T pallidum-specific IgM antibodies. Finally, new insights into the role of antibody correlations between serum and cerebrospinal fluid are mentioned that have established the detection of asymptomatic neurosyphilis.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Antibodies, Bacterial / analysis*
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Antibodies, Bacterial / biosynthesis
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Antibody Specificity
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Humans
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Immunoglobulin G / analysis
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Immunoglobulin G / biosynthesis
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Immunoglobulin M / analysis
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Immunoglobulin M / biosynthesis
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Infant
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Infant, Newborn
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Male
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Neurosyphilis / diagnosis
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Neurosyphilis / immunology
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Penicillins / therapeutic use
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Syphilis / drug therapy
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Syphilis / immunology
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Syphilis Serodiagnosis / methods*
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Syphilis, Congenital / diagnosis
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Treponema pallidum / immunology
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Treponemal Infections / diagnosis*
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Treponemal Infections / drug therapy
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Treponemal Infections / immunology
Substances
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Antibodies, Bacterial
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Immunoglobulin G
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Immunoglobulin M
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Penicillins