Novel uses of laser therapy in Goltz syndrome

Dermatol Ther. 2022 May;35(5):e15371. doi: 10.1111/dth.15371. Epub 2022 Feb 17.

Abstract

Goltz syndrome is an X-linked dominant, multisystem birth defect due to PORCN mutation. The skin findings follow Blaschko's lines and often show epidermal atrophy and herniation of subcutaneous fatty tissue. Regarding treatment, light sources can offer a good therapeutic option for some manifestations of this rare disease and improve the aesthetic appearance of the skin lesions. We report two new cases of Goltz syndrome in which the cutaneous findings remarkably improved with pulsed dye laser and carbon dioxide laser.

Keywords: Goltz syndrome; Goltz-Gorlin syndrome; focal dermal hypoplasia; functional X-chromosome mosaicism; laser.

MeSH terms

  • Acyltransferases / genetics
  • Focal Dermal Hypoplasia* / diagnosis
  • Focal Dermal Hypoplasia* / genetics
  • Focal Dermal Hypoplasia* / pathology
  • Humans
  • Laser Therapy*
  • Membrane Proteins / genetics
  • Mutation

Substances

  • Membrane Proteins
  • Acyltransferases
  • PORCN protein, human