Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment

Julia Natterer; Frida Rizzati; Marie-Hélène Perez; David Longchamp; Vivianne Amiet; Quentin DeHalleux; Kim Dao; Thomas Ferry

doi:10.1055/s-0040-1714707

Suspected Case of Drug-Induced Acute Respiratory Distress Syndrome following Trimethoprim-Sulfamethoxazole Treatment

J Pediatr Intensive Care. 2020 Jul 30;11(1):67-71. doi: 10.1055/s-0040-1714707. eCollection 2022 Mar.

Authors

Julia Natterer¹, Frida Rizzati¹, Marie-Hélène Perez¹, David Longchamp¹, Vivianne Amiet¹, Quentin DeHalleux², Kim Dao³, Thomas Ferry¹

Affiliations

¹ Pediatric Intensive Care Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland.
² Pediatric Physiotherapy Unit, Women, Mothers and Children's Department, Faculty of Medicine and Biology, Lausanne University Hospital, Lausanne, Switzerland.
³ Service of Clinical Pharmacology, Department of Laboratories Medicine and Pathology, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Abstract

In this article, we reported the case of a child patient who was admitted to our PICU for severe acute respiratory distress syndrome (ARDS) while being treated with trimethoprim-sulfamethoxazole (TMP-SMX) for osteomyelitis. Based on the timing of exposure, lack of alternative explanations, and clinical course similar to previously described cases, we suspect that TMP-SMX may have triggered ARDS. Despite meeting criteria for extracorporeal membrane oxygenation cannulation, conservative management and lung recruitment with high-frequency percussive ventilation could avoid the latter.

Keywords: acute respiratory distress syndrome; percussive ventilation; trimethoprim.

Publication types

Case Reports