Large Animal Models of Breast Cancer

Pinaki Mondal; Katie L Bailey; Sara B Cartwright; Vimla Band; Mark A Carlson

doi:10.3389/fonc.2022.788038

Large Animal Models of Breast Cancer

Front Oncol. 2022 Feb 4:12:788038. doi: 10.3389/fonc.2022.788038. eCollection 2022.

Authors

Pinaki Mondal^{1

2}, Katie L Bailey¹, Sara B Cartwright¹, Vimla Band^{3

4}, Mark A Carlson^{1

2

3

4

5}

Affiliations

¹ Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States.
² Department of Surgery, VA Medical Center, Omaha, NE, United States.
³ Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE, United States.
⁴ Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, United States.
⁵ Center for Advanced Surgical Technology, University of Nebraska Medical Center, Omaha, NE, United States.

Abstract

In this mini review the status, advantages, and disadvantages of large animal modeling of breast cancer (BC) will be discussed. While most older studies of large animal BC models utilized canine and feline subjects, more recently there has been interest in development of porcine BC models, with some early promising results for modeling human disease. Widely used rodent models of BC were briefly reviewed to give context to the work on the large animal BC models. Availability of large animal BC models could provide additional tools for BC research, including availability of human-sized subjects and BC models with greater biologic relevance.

Keywords: BRCA1; TP53; animal models; breast cancer; large animal models; porcine model.

Publication types

Review

Grants and funding

R01 CA222907/CA/NCI NIH HHS/United States