Thematic trend mapping and hotspot analysis in bone marrow aspirate concentrate therapy: A scientometric literature analysis and advances in osteoarthritis

Cytotherapy. 2022 May;24(5):445-455. doi: 10.1016/j.jcyt.2022.01.002. Epub 2022 Feb 18.

Abstract

Bone marrow aspirate concentrate (BMAC) therapy has been spotlighted as a promising regenerative tool with its abundant source of mesenchymal stromal cells (MSCs) and growth factors. The spectrum of the utility of BMAC therapy has been expanding day by day to harness the potential for varied therapeutic purposes. In the due course of its evolution, it is often essential to have a comprehensive summary of progress to have a greater understanding and refine our future directives. With technological developments such as data mining, graphic drawing and information analytics combined with computational statistics, visualization of scientific metrology has become a reality. With this newer perspective, we intend to use scientometric tools including text mining, cocitation analysis, keyword analysis and cluster network analysis to perform thematic trend mapping and hotspot analysis of the literature on BMAC therapy and evaluate its progress in the management of osteoarthritis.

Keywords: bone marrow aspirate concentrate; mesenchymal stromal cells; osteoarthritis.

Publication types

  • Review

MeSH terms

  • Bone Marrow
  • Bone Marrow Transplantation
  • Humans
  • Mesenchymal Stem Cells*
  • Osteoarthritis* / therapy