Percutaneous Closure of Patent Ductus Arteriosus

Megan Barcroft; Christopher McKee; Darren P Berman; Rachel A Taylor; Brian K Rivera; Charles V Smith; Jonathan L Slaughter; Afif El-Khuffash; Carl H Backes

doi:10.1016/j.clp.2021.11.009

Percutaneous Closure of Patent Ductus Arteriosus

Clin Perinatol. 2022 Mar;49(1):149-166. doi: 10.1016/j.clp.2021.11.009. Epub 2022 Jan 21.

Authors

Megan Barcroft¹, Christopher McKee², Darren P Berman³, Rachel A Taylor³, Brian K Rivera⁴, Charles V Smith⁵, Jonathan L Slaughter⁶, Afif El-Khuffash⁷, Carl H Backes⁸

Affiliations

¹ Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
² Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Department of Anesthesiology, Nationwide Children's Hospital, Columbus, OH, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
³ Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA.
⁴ Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
⁵ Center for Integrated Brain Research, Seattle Children's Research Institute, Seattle, WA, USA.
⁶ Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, USA.
⁷ Department of Neonatology, The Rotunda Hospital, Dublin, Ireland; Department of Paediatrics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
⁸ Department of Pediatrics, The Ohio State University Wexner Medical Center, Columbus, OH, USA; The Heart Center, Nationwide Children's Hospital, Columbus, OH, USA; Center for Perinatal Research, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. Electronic address: [email protected].

Abstract

Percutaneous-based patent ductus arteriosus closure is technically feasible among infants less than 1.5 kg. However, marked heterogeneity in the type and nature of adverse events obscures current safety profile assessments. Although data on the risks of postdevice closure syndrome remain promising, a lack of comparative trials of surgical ductal ligation and inconsistent surveillance across published studies obscure confidence in present estimates of safety and efficacy. To minimize risk and yield the greatest benefits, clinical studies of patent ductus arteriosus treatment should consider incorporating more robust assessments to ensure that infants at greatest risk for adverse ductal consequences are included.

Keywords: Catheter-based closure; Patent ductus arteriosus; Percutaneous closure; Preterm infant; Very low birth weight infant.

Publication types

Research Support, N.I.H., Extramural
Review

MeSH terms

Ductus Arteriosus, Patent* / surgery
Humans
Infant
Infant, Newborn
Infant, Premature
Ligation
Treatment Outcome

Grants and funding

R01 HL145032/HL/NHLBI NIH HHS/United States