The analgesic and antidepressant properties of dihydroartemisinine in the neuropathic pain mice: By the downregulation of HnRNPA1 in the spinal cord and hippocampus

Clin Transl Med. 2022 Feb;12(2):e751. doi: 10.1002/ctm2.751.

Authors

Chunyan Zhu¹, Yongping Zhu², Guoxin Zhang¹, Hongyan Wu¹, Yuqi Shi¹, Jiahao Li¹, Jun Yang¹, Zhiyun Mao¹, Qionghong Xu¹, Xuemin Yao¹, Xiaoxin Zhu¹, Jigang Wang², Xianguo Liu³, Na Lin¹

Affiliations

¹ Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
² Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China.
³ Department of Physiology and Pain Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, 510080, China.

No abstract available

Publication types

Letter

MeSH terms

Analgesics / metabolism
Analgesics / pharmacology
Animals
Antidepressive Agents / metabolism
Antidepressive Agents / pharmacology
Artemisinins / metabolism
Artemisinins / pharmacology*
Disease Models, Animal
Heterogeneous Nuclear Ribonucleoprotein A1 / drug effects*
Hippocampus / drug effects
Mice
Neuralgia / drug therapy*
Neuralgia / physiopathology
Spinal Cord / drug effects

Substances

Analgesics
Antidepressive Agents
Artemisinins
Heterogeneous Nuclear Ribonucleoprotein A1
Hnrnpa1 protein, mouse
artenimol

Grants and funding