Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) exposure investigations using genomic sequencing among healthcare workers and patients in a large academic center

Leigh Smith; C Paul Morris; Morgan H Jibowu; Susan Fallon; Stuart C Ray; Sara E Cosgrove; Melanie S Curless; Valeria Fabre; Sara M Karaba; Lisa L Maragakis; Aaron M Milstone; Anna C Sick-Samuels; Polly Trexler; Heba H Mostafa; Clare Rock; CDC Prevention Epicenter Program

doi:10.1017/ice.2022.37

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) exposure investigations using genomic sequencing among healthcare workers and patients in a large academic center

Infect Control Hosp Epidemiol. 2023 May;44(5):798-801. doi: 10.1017/ice.2022.37. Epub 2022 Mar 2.

Authors

Leigh Smith^#^{1

2}, C Paul Morris^#^{3

4}, Morgan H Jibowu², Susan Fallon², Stuart C Ray¹, Sara E Cosgrove^{1

2}, Melanie S Curless², Valeria Fabre^{1

2}, Sara M Karaba¹, Lisa L Maragakis^{1

2}, Aaron M Milstone^{2

5}, Anna C Sick-Samuels^{2

5}, Polly Trexler², Heba H Mostafa^#³, Clare Rock^#^{1

2}; CDC Prevention Epicenter Program

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland.
² Department of Hospital Epidemiology and Infection Control, Johns Hopkins Hospital, Baltimore, Maryland.
³ Division of Medical Microbiology, Department of Pathology, Johns Hopkins Hospital, Baltimore, Maryland.
⁴ National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland.
⁵ Division of Infectious Diseases, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

^# Contributed equally.

Abstract

Severe acute respiratory coronavirus virus 2 (SARS-CoV-2) transmissions among healthcare workers and hospitalized patients are challenging to confirm. Investigation of infected persons often reveals multiple potential risk factors for viral acquisition. We combined exposure investigation with genomic analysis confirming 2 hospital-based clusters. Prolonged close contact with unmasked, unrecognized infectious, individuals was a common risk.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.
Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Health Personnel
Hospitals
Humans
Risk Factors
SARS-CoV-2*

Abstract

Publication types

MeSH terms

Grants and funding