Targeting Local Recurrence After Surgery With MRI Imaging for Prostate Cancer in the Setting of Salvage Radiation Therapy

Raphaële Renard-Penna; Jules Zhang-Yin; Sarah Montagne; Laurene Aupin; Eric Bruguière; Mouna Labidi; Igor Latorzeff; Christophe Hennequin

doi:10.3389/fonc.2022.775387

Targeting Local Recurrence After Surgery With MRI Imaging for Prostate Cancer in the Setting of Salvage Radiation Therapy

Front Oncol. 2022 Feb 15:12:775387. doi: 10.3389/fonc.2022.775387. eCollection 2022.

Authors

Raphaële Renard-Penna^{1

2}, Jules Zhang-Yin³, Sarah Montagne^{1

2}, Laurene Aupin¹, Eric Bruguière⁴, Mouna Labidi⁵, Igor Latorzeff⁶, Christophe Hennequin⁵

Affiliations

¹ Academic Department of Radiology, Hôpital Pitié-Salpétrière, Assistance Publique des Hôpitaux de Paris, Paris, France.
² Sorbonne University, Paris, France.
³ Nuclear Medicine Department, Tenon Hospital, Assistance Publique des Hôpitaux de Paris (APHP), Paris, France.
⁴ Department of Imaging, Clinique Pasteur, Toulouse, France.
⁵ Department of Oncology, Saint-Louis Hospital, Université de Paris, Assistance Publique des Hôpitaux de Paris, Paris, France.
⁶ Department of Radiotherapy, Clinique Pasteur, Toulouse, France.

Abstract

Magnetic resonance imaging (MRI) is being increasingly used for imaging suspected recurrence in prostate cancer therapy. Functional MRI with diffusion and perfusion imaging has the potential to demonstrate local recurrence even at low PSA value. Detection of recurrence can modify the management of postprostatectomy biochemical recurrence. MRI scan acquired before salvage radiotherapy is useful for the localization of recurrent tumors and also in the delineation of the target volume. The objective of this review is to assess the role and potential impact of MRI in targeting local recurrence after surgery for prostate cancer in the setting of salvage radiation therapy.

Keywords: MRI; diffusion magnetic resonance imaging; local neoplasm recurrence; prostate cancer; prostatectomy; radiation therapy.

Publication types

Review