Prognostic value of H₂FPEF score in COVID-19

Study objective: This study sought to assess the predictive value of H₂FPEF score in patients with COVID-19.

Design: Retrospective study.

Setting: Rush University Medical Center.

Participants: A total of 1682 patients had an echocardiogram in the year preceding their COVID-19 admission with a preserved ejection fraction (≥50%). A total of 156 patients met inclusion criteria.

Interventions: Patients were divided into H₂FPEF into low (0-2), intermediate (3-5), and high (6-9) score H₂FPEF groups and outcomes were compared.

Main outcome measures: Adjusted multivariable logistic regression models evaluated the association between H₂FPEF score group and a composite outcome for severe COVID-19 infection consisting of (1) 60-day mortality or illness requiring (2) intensive care unit, (3) intubation, or (4) non-invasive positive pressure ventilation.

Results: High H₂FPEF scores were at increased risk for severe COVID-19 infection when compared intermediate to H₂FPEF score groups (OR 2.18 [CI: 1.01-4.80]; p = 0.049) and low H₂FPEF score groups (OR 2.99 [CI: 1.22-7.61]; p < 0.05). There was no difference in outcome between intermediate H₂FPEF scores (OR 1.34 [CI: 0.59-3.16]; p = 0.489) and low H₂FPEF score.

Conclusions: Patients with a high H₂FPEF score were at increased risk for severe COVID-19 infection when compared to patients with an intermediate or low H₂FPEF score regardless of regardless of coronary artery disease and chronic kidney disease.