Roles of Gut Microbiota in Colorectal Carcinogenesis Providing a Perspective for Early Diagnosis and Treatment

Curr Pharm Biotechnol. 2022;23(13):1569-1580. doi: 10.2174/1389201023666220307112413.

Abstract

Colorectal cancer (CRC) is the third most prevalent malignant neoplasm in the world. CRC is influenced by both environmental and genetic factors. Through toxin-mediated DNA damage and the promotion of persistent dysregulated inflammation, the gut microbiota plays a crucial role in the development of CRC. In this review, we discussed the correlation between the bacterial microbiota and CRC carcinogenesis as well as the mechanism by which Streptococcus bovis/gallolyticus, Fusobacterium nucleatum, Bacteroides fragilis, and Escherichia coli can cause CRC.

Keywords: Gut microbiota; bacteria; carcinogenesis; colorectal cancer; genotoxicity; inflammation.

Publication types

  • Review

MeSH terms

  • Bacteria / genetics
  • Carcinogenesis / genetics
  • Colorectal Neoplasms* / diagnosis
  • Colorectal Neoplasms* / pathology
  • Colorectal Neoplasms* / therapy
  • Early Detection of Cancer
  • Escherichia coli
  • Gastrointestinal Microbiome*
  • Humans