OShnscc: a novel user-friendly online survival analysis tool for head and neck squamous cell carcinoma based on RNA expression profiles and long-term survival information

J Zhejiang Univ Sci B. 2022 Mar 15;23(3):249-257. doi: 10.1631/jzus.B2100512.

Abstract

Head and neck squamous cell carcinoma (HNSCC), as the most common type (>90%) of head and neck cancer, includes various epithelial malignancies that arise in the nasal cavity, oral cavity, pharynx, and larynx. In 2020, approximately 878 ‍ 000 new cases and 444 000 deaths linked to HNSCC occurred worldwide (Sung et al., 2021). Due to the associated frequent recurrence and metastasis, HNSCC patients have poor prognosis with a five-year survival rate of 40%-50% (Jou and Hess, 2017). Therefore, novel prognostic biomarkers need to be developed to identify high-risk HNSCC patients and improve their disease outcomes.

Keywords: Head and neck squamous cell carcinoma; Kaplan-Meier curve; OShnscc; Online survival tool; Prognostic biomarker.

MeSH terms

  • Biomarkers, Tumor / genetics
  • Head and Neck Neoplasms* / genetics
  • Humans
  • Kaplan-Meier Estimate
  • RNA
  • Squamous Cell Carcinoma of Head and Neck
  • Survival Analysis
  • Survival Rate

Substances

  • Biomarkers, Tumor
  • RNA