Disseminated Aspergillus lentulus Infection in a Heart Transplant Recipient: A Case Report

Gowri Shivasabesan; Bentley Logan; Xavier Brennan; Cindy Lau; Anagha Vaze; Michael Bennett; Natasha Gorrie; Feras Mirdad; Ricardo Deveza; Chung Mo Koo; Peter McCluskey; Peter Macdonald; Deborah Marriott; Kavitha Muthiah; Nila P Dharan

doi:10.1093/cid/ciac205

Disseminated Aspergillus lentulus Infection in a Heart Transplant Recipient: A Case Report

Clin Infect Dis. 2022 Sep 30;75(7):1235-1238. doi: 10.1093/cid/ciac205.

Authors

Gowri Shivasabesan¹, Bentley Logan², Xavier Brennan¹, Cindy Lau^{1

3}, Anagha Vaze^{2

4}, Michael Bennett^{1

5}, Natasha Gorrie¹, Feras Mirdad¹, Ricardo Deveza¹, Chung Mo Koo¹, Peter McCluskey^{2

4}, Peter Macdonald¹, Deborah Marriott¹, Kavitha Muthiah¹, Nila P Dharan^{1

6}

Affiliations

¹ St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia.
² Sydney Eye Hospital, Sydney, New South Wales, Australia.
³ School of Pharmacy, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.
⁴ Save Sight Institute, Faculty of Medicine & Health University, Sydney, New South Wales, Australia.
⁵ Department of Medicine, University of New South Wales - Sydney, Sydney, New South Wales, Australia.
⁶ Kirby Institute, University of New South Wales, Sydney, Sydney, New South Wales, Australia.

PMID: 35275984
DOI: 10.1093/cid/ciac205

Abstract

We present the first published case of successfully treated disseminated Aspergillus lentulus infection in a solid organ transplant recipient with invasive pulmonary disease, endophthalmitis, and a cerebral abscess. This case highlights important challenges associated with treating A. lentulus, particularly regarding antifungal resistance and toxicities associated with long-term antifungal therapy.

Keywords: Aspergillus lentulus; case report; endophthalmitis; invasive aspergillosis; solid organ transplant.

Publication types

Case Reports

MeSH terms

Antifungal Agents* / pharmacology
Antifungal Agents* / therapeutic use
Aspergillus
Drug Resistance, Fungal
Heart Transplantation* / adverse effects
Humans

Substances

Antifungal Agents

Supplementary concepts

Aspergillus lentulus