Inadequacy of PCR genotyping in advanced non-small cell lung cancer: EGFR L747_A755delinsSS exon 19 deletion is not detected by the real-time PCR Idylla™ EGFR mutation test but is detected by ctDNA next generation sequencing and responds to osimertinib

MeSH terms

• Acrylamides
• Aniline Compounds / therapeutic use
• Carcinoma, Non-Small-Cell Lung* / drug therapy
• Carcinoma, Non-Small-Cell Lung* / genetics
• Circulating Tumor DNA* / genetics
• ErbB Receptors / genetics
• Exons
• Genotype
• High-Throughput Nucleotide Sequencing
• Humans
• Lung Neoplasms* / drug therapy
• Lung Neoplasms* / genetics
• Mutation
• Protein Kinase Inhibitors / therapeutic use
• Real-Time Polymerase Chain Reaction