Wild-Type Human PRSS2 and PRSS1R122H Cooperatively Initiate Spontaneous Hereditary Pancreatitis in Transgenic Mice

Gastroenterology. 2022 Jul;163(1):313-315.e4. doi: 10.1053/j.gastro.2022.03.009. Epub 2022 Mar 11.
No abstract available

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Mice
  • Mice, Transgenic
  • Mutation
  • Pancreatitis, Chronic*
  • Trypsin / genetics
  • Trypsinogen / genetics

Substances

  • PRSS2 protein, human
  • Trypsinogen
  • PRSS1 protein, human
  • Trypsin

Supplementary concepts

  • Hereditary pancreatitis