Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

Adam M Brickman; Jennifer J Manly; Lawrence S Honig; Danurys Sanchez; Dolly Reyes-Dumeyer; Rafael A Lantigua; Jean Paul Vonsattel; Andrew F Teich; Min Suk Kang; Jeffrey L Dage; Richard Mayeux

doi:10.1002/acn3.51529

Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease

Ann Clin Transl Neurol. 2022 May;9(5):756-761. doi: 10.1002/acn3.51529. Epub 2022 Mar 20.

Authors

Adam M Brickman^{1

2

3}, Jennifer J Manly^{1

2

3}, Lawrence S Honig^{1

2

3}, Danurys Sanchez^{1

2

3}, Dolly Reyes-Dumeyer^{1

2

3}, Rafael A Lantigua^{1

4}, Jean Paul Vonsattel^{1

5}, Andrew F Teich^{1

5}, Min Suk Kang¹, Jeffrey L Dage⁶, Richard Mayeux^{1

2

3}

Affiliations

¹ Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
² G.H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
³ Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, New York, USA.
⁴ Department of Medicine, Vagelos College of Physicians and Surgeons, Columbia University, and the New York Presbyterian Hospital, New York, New York, USA.
⁵ Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
⁶ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Abstract

Blood-based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort study, participants were classified as biomarker positive (Ptau+) or negative (Ptau-) based on Ptau 181 and 217 concentrations and as cognitively impaired (Sym) or unimpaired (Asym). The four groups, Ptau-/Asym, Ptau+/Asym, Ptau-/Sym, and Ptau+/Sym, differed by age, APOE-4 allele frequency, total tau, neurofilament light chain, and cortical thickness measured by MRI. Our results add to increasing evidence that plasma Ptau 181 and 217 concentrations are valid Alzheimer's disease biomarkers in diverse populations.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Alzheimer Disease* / diagnostic imaging
Biomarkers
Cohort Studies
Humans
Magnetic Resonance Imaging
Neuroimaging

Substances

Biomarkers

Abstract

Publication types

MeSH terms

Substances

Grants and funding