[Cytochrome pharmacogenetics applied to the prescription of antidepressants: Instructions for use]

Encephale. 2022 Aug;48(4):462-471. doi: 10.1016/j.encep.2021.12.008. Epub 2022 Mar 21.
[Article in French]

Abstract

CYP2D6 and CYP2C19 polymorphisms affect the exposure, efficacy, and safety of antidepressants. This article is an instruction manual and a guide for the deployment, in hospitals, of pharmacogenetics as an aid to the prescription of an antidepressant. It synthesizes the recommendations of two learned societies, the Clinical Pharmacogenetics Implementation Consortium (CPIC) and the Dutch Pharmacogenetics Working Group (DPWG), to produce a recommendation table adapted to a wide panel of antidepressants.

Keywords: Aide à la prescription; Antidepressants; Antidépresseur; Cytochrome; Depression; Dépression; Pharmacogenetics; Pharmacogénétique; Prescription assistance.

MeSH terms

  • Antidepressive Agents / adverse effects
  • Cytochrome P-450 CYP2D6* / genetics
  • Humans
  • Pharmacogenetics*
  • Polymorphism, Genetic
  • Prescriptions

Substances

  • Antidepressive Agents
  • Cytochrome P-450 CYP2D6