Alkynyl Borrowing: Silver-Catalyzed Amination of Secondary Propargylic Alcohols via C(sp3)-C(sp) Bond Cleavage

J Org Chem. 2022 Apr 15;87(8):5395-5403. doi: 10.1021/acs.joc.2c00297. Epub 2022 Apr 6.

Abstract

The silver-catalyzed alkynyl borrowing amination of secondary propargyl alcohols via C(sp3)-C(sp) bond cleavage has been developed. This new strategy was based on the β-alkynyl elimination of propargyl alcohols and alkynyl as the borrowing subject. This alkynyl borrowing amination featured high atom economy, wide functional group tolerance, and high efficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohols* / chemistry
  • Amination
  • Catalysis
  • Silver* / chemistry

Substances

  • Alcohols
  • Silver