Unlocking the secrets to Janus kinase activation

Science. 2022 Apr 8;376(6589):139-140. doi: 10.1126/science.abo7788. Epub 2022 Apr 7.

Authors

Ross L Levine¹, Stevan R Hubbard²

Affiliations

¹ Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
² Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY, USA.

PMID: 35389811
DOI: 10.1126/science.abo7788

Abstract

The full-length structure of a Janus kinase provides insights for drug development.

Publication types

Comment

MeSH terms

Drug Development*
Enzyme Activation*
Janus Kinase 2*
Janus Kinases*

Substances

Janus Kinase 2
Janus Kinases