Epigenetic switch controls social actions

Giorgia Pedini; Claudia Bagni

doi:10.1016/j.neuron.2022.03.028

Epigenetic switch controls social actions

Neuron. 2022 Apr 6;110(7):1085-1087. doi: 10.1016/j.neuron.2022.03.028.

Authors

Giorgia Pedini¹, Claudia Bagni²

Affiliations

¹ University of Lausanne, Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005 Lausanne, Switzerland; University of Rome Tor Vergata, Department of Biomedicine and Prevention, Via Montpellier 1, 00133 Rome, Italy.
² University of Lausanne, Department of Fundamental Neurosciences, Rue du Bugnon 9, 1005 Lausanne, Switzerland; University of Rome Tor Vergata, Department of Biomedicine and Prevention, Via Montpellier 1, 00133 Rome, Italy. Electronic address: [email protected].

PMID: 35390284
DOI: 10.1016/j.neuron.2022.03.028

Abstract

Mutations in epigenetic factors are associated with autism spectrum disorder (ASD). In this issue of Neuron, Yan et al. (2022) show that the antagonism of ASH1L and PRC2 switches the equilibrium of histone methylation at the ephrin receptor A7 locus, causing decreased EphA7 expression, deficits in synaptic pruning, and ASD-like behaviors.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Autism Spectrum Disorder* / genetics
Autism Spectrum Disorder* / metabolism
Epigenesis, Genetic
Epigenomics
Humans
Mutation / genetics