[Efficiency and safety of peptide receptor radionuclide therapy in the treatment of metastatic neuroendocrine tumors]

Zhonghua Yi Xue Za Zhi. 2022 Apr 12;102(14):1034-1038. doi: 10.3760/cma.j.cn112137-20211223-02872.
[Article in Chinese]

Abstract

The clinical data of 14 patients with neuroendocrine tumors who received Peptide Receptor Radionuclide Therapy (PRRT) from December 2018 to May 2021 were retrospectively analyzed. Among them, 2 patients demonstrated proprogressive disease, 2 patients had partial response, and 10 patients had stable disease. Grade 1-2 myelosuppression occurred in 5 patients. and 1 patient became grade 3 myelosuppression,which recovered to grade 2 after symptomatic treatment. No grade 2 or higher treatment-related renal toxicity was observed in any of the patients. PRRT is efficacy and no significant side effects for unresectable metastatic neuroendocrine tumors.

回顾性分析2018年12月至2021年5月接受肽受体放射性核素治疗(PRRT)的14例神经内分泌肿瘤患者资料,其中2例疾病进展,2例部分缓解,10例病情稳定。5例出现1~2级骨髓抑制,1例出现3级骨髓抑制,经对症治疗后恢复至2级。所有患者均未发现2级以上治疗相关性肾脏毒性。PRRT对于无法手术切除的转移性神经内分泌肿瘤有较好疗效,无明显不良反应。.

MeSH terms

  • Humans
  • Neuroendocrine Tumors* / radiotherapy
  • Octreotide / therapeutic use
  • Radioisotopes / therapeutic use
  • Receptors, Peptide / therapeutic use
  • Retrospective Studies

Substances

  • Radioisotopes
  • Receptors, Peptide
  • Octreotide