Turning end-joining upside down in mitosis

Marta Llorens-Agost; Michael Ensminger; Hang Phuong Le; Wolf-Dietrich Heyer; Markus Löbrich

doi:10.1080/23723556.2021.2007029

Turning end-joining upside down in mitosis

Mol Cell Oncol. 2021 Nov 23;8(6):2007029. doi: 10.1080/23723556.2021.2007029. eCollection 2021.

Authors

Marta Llorens-Agost¹, Michael Ensminger¹, Hang Phuong Le², Wolf-Dietrich Heyer², Markus Löbrich¹

Affiliations

¹ Radiation Biology and DNA Repair, Technical University of Darmstadt, Darmstadt, Germany.
² Department of Microbiology and Molecular Genetics, University of California, Davis, Davis, CA, USA.

Abstract

How cells deal with DNA breaks during mitosis is not well understood. While canonical non-homologous end-joining predominates in interphase, it is inhibited in mitosis to avoid telomere fusions. DNA polymerase θ mediated end-joining appears to be repressed in interphase, but promotes break repair in mitosis. The nature and induction time of breaks might determine their fate during mitosis.

Keywords: DNA repair; TMEJ; c-NHEJ; mitosis; tethering.

Abstract

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