SnapShot: Regulation and biology of PGC-1α

Paulo R Jannig; Phillip A Dumesic; Bruce M Spiegelman; Jorge L Ruas

doi:10.1016/j.cell.2022.03.027

SnapShot: Regulation and biology of PGC-1α

Cell. 2022 Apr 14;185(8):1444-1444.e1. doi: 10.1016/j.cell.2022.03.027.

Authors

Paulo R Jannig¹, Phillip A Dumesic², Bruce M Spiegelman², Jorge L Ruas¹

Affiliations

¹ Department of Physiology and Pharmacology, Biomedicum, Karolinska Institutet, 17165 Stockholm, Sweden.
² Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.

PMID: 35427500
DOI: 10.1016/j.cell.2022.03.027

Abstract

The peroxisome proliferator-activated receptor γ coactivator-1α (Ppargc1a) gene encodes several PGC-1α isoforms that regulate mitochondrial bioenergetics and cellular adaptive processes. Expressing specific PGC-1α isoforms in mice can confer protection in different disease models. This SnapShot summarizes how regulation of Ppargc1a transcription, splicing, translation, protein stability, and activity underlies its multifaceted functions. To view this SnapShot, open or download the PDF.

MeSH terms

Animals
Biology
Energy Metabolism
Gene Expression Regulation*
Mice
Mitochondria* / genetics
Mitochondria* / metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / genetics
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha / metabolism
Protein Isoforms / genetics
Protein Isoforms / metabolism

Substances

Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
Protein Isoforms