In this study, the influences of marine red yeast Rhodosporidium paludigenum (MRYP) on diarrhea rate, serum antioxidant capacity, intestinal immunity capacity, and microflora structure of early-weaned lamb were investigated in a 60-day feeding trial. A total of 96 early-weaned lambs were utilized in this study. The lambs were divided into four experimental groups based on the percentage of marine red yeast Rhodosporidium paludigenum (MRYP) as milk replacer supplement. The rates of milk replacer supplement for the four groups were 0, 0.1%, 0.3%, and 0.5% of marine red yeast Rhodosporidium paludigenum (MRYP), respectively. The study was continued for 30 days. The results showed that (1) compared with control group, 0.5% marine red yeast Rhodosporidium paludigenum (MRYP) supplementation caused significantly decreases in average fecal score and diarrhea frequency by 33.74% and 40.23% (P < 0.05). (2) No significant difference was found in all tested related antioxidant indexes in serum of four treatments (P > 0.05). (3) The concentrations of SIgA, IgG, and IL-10 of group IV was significantly increased by 17.78%, 18.27%, and 8.17%, but the IL-6 and TNF-α were significantly decreased by 21.20% and 31.80%, compared to group I in the colon (P < 0.05). (4) The number of Bifidobacterial and Lactobacilli of group IV was significantly increased by 14.87% and 15.09%, but Escherichia coli and Salmonella were significantly decreased by 20.19% and 10.15%, compared to group I in the colon (P < 0.05). (5) A portion of marine red yeast Rhodosporidium paludigenum (MRYP) survived in the intestine of early-weaned lamb, and the number of survival marine red yeast Rhodosporidium paludigenum (MRYP) increased as the addition of marine red yeast Rhodosporidium paludigenum (MRYP) increased from 0.1 to 0.5% in milk replacer. Therefore, marine red yeast Rhodosporidium paludigenum (MRYP) has a potential to be a replacer of antibiotics for prevention and treatment of diarrhea in early-weaned lambs.
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