Mechanisms of cancer stem cells drug resistance and the pivotal role of HMGA2

Huldani Huldani; Saade Abdalkareem Jasim; Klunko Nataliya Sergeenva; Dmitry Olegovich Bokov; Walid Kamal Abdelbasset; Rustam Turakulov; Moaed E Al-Gazally; Behnam Ahmadzadeh; Zanko Hassan Jawhar; Homayoon Siahmansouri

doi:10.1016/j.prp.2022.153906

Mechanisms of cancer stem cells drug resistance and the pivotal role of HMGA2

Pathol Res Pract. 2022 Jun:234:153906. doi: 10.1016/j.prp.2022.153906. Epub 2022 Apr 19.

Affiliations

¹ Department of Physiology, Lambung Mangkurat University, Banjarmasin, South Borneo, Indonesia.
² Medical Laboratory Techniques Department, Al-Maarif University College, Al-Anbar-Ramadi, Iraq.
³ Department of post-graduate and doctoral programs, Russian New University, Building 5, Radio Street, Moscow City, Russian Federation.
⁴ Institute of Pharmacy, Sechenov First Moscow State Medical University, 8 Trubetskaya St., Bldg. 2, Moscow 119991, Russian Federation.
⁵ Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam bin Abdulaziz University, Al Kharj, Saudi Arabia; Department of Physical Therapy, Kasr Al-Aini Hospital, Cairo University, Giza, Egypt.
⁶ Department of Internal diseases, Tashkent Medical Academy, Tashkent, Uzbekistan.
⁷ College of medicine, University of Al-Ameed, Karbala, Iraq.
⁸ Doctoral School of the University of Szczecin, Institute of Biology, University of Szczecin, 71-412 Szczecin, Poland.
⁹ Department of Medical Laboratory Science, College of Health Science, Lebanese French University, Kurdistan Region, Iraq.
¹⁰ Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: [email protected].

PMID: 35468338
DOI: 10.1016/j.prp.2022.153906

Abstract

Nowadays, the focus of researchers is on perceiving the heterogeneity observed in a tumor. The researchers studied the role of a specific subset of cancer cells with high resistance to traditional treatments, recurrence, and unregulated metastasis. This small population of tumor cells that have stem-cell-like specifications was named Cancer Stem Cells (CSCs). The unique features that distinguish this type of cancer cell are self-renewing, generating clones of the tumor, plasticity, recurrence, and resistance to therapies. There are various mechanisms that contribute to the drug resistance of CSCs, such as CSCs markers, Epithelial mesenchymal transition, hypoxia, other cells, inflammation, and signaling pathways. Recent investigations have revealed the primary role of HMGA2 in the development and invasion of cancer cells. Importantly, HMGA2 also plays a key role in resistance to treatment through their function in the drug resistance mechanisms of CSCs and challenge it. Therefore, a deep understanding of this issue can provide a clearer perspective for researchers in the face of this problem.

Keywords: Cancer stem cells; Chemo-resistance; Drug resistance; HMGA2.

Publication types

Review

MeSH terms

Drug Resistance, Neoplasm
Epithelial-Mesenchymal Transition
Humans
Neoplasms* / pathology
Neoplastic Stem Cells* / pathology
Signal Transduction