Dalbavancin in clinical practice: a particular place for the elderly?

Eur J Clin Microbiol Infect Dis. 2022 Jun;41(6):977-979. doi: 10.1007/s10096-022-04427-2. Epub 2022 Apr 26.

Abstract

We investigate dalbavancin efficiency and tolerance among elderly in Grenoble-Alpes 32 university hospital. Among the 65 patients who received dalbavancin, 51% (33) were considered as old. Patients presented mainly bones and joint infections (52%), surgical site infection 34 (31%), and infective endocarditis (IE) (8%). Clinical cure was confirmed for 79% of old 35 patients at 1, 3, and 6 months. Six adverse events (9%) were reported after 36 dalbavancin's administration, but each time in combination with other antibiotics. 37 Dalbavancin had a significant effectiveness and safety profile and represents a real 38 therapeutic option in the management of deep and complex infections of elderly patients.

Keywords: Aged; Anti-bacterial agents; Arthritis; Bone diseases, infectious; Comorbidity.

MeSH terms

  • Aged
  • Anti-Bacterial Agents / adverse effects
  • Endocarditis, Bacterial* / drug therapy
  • Gram-Positive Bacterial Infections* / drug therapy
  • Humans
  • Teicoplanin / adverse effects
  • Teicoplanin / analogs & derivatives

Substances

  • Anti-Bacterial Agents
  • Teicoplanin
  • dalbavancin