Letermovir for Cytomegalovirus Prevention in Adolescent Patients Following Hematopoietic Cell Transplantation

J Pediatric Infect Dis Soc. 2022 Jul 21;11(7):337-340. doi: 10.1093/jpids/piac017.

Abstract

There are limited data for letermovir as primary cytomegalovirus (CMV) prophylaxis in patients less than 18 years of age. We report 9 adolescent patients who received letermovir following hematopoietic cell transplantation. No patients developed clinically significant CMV while taking letermovir. Letermovir was well tolerated and efficacious in preventing CMV infections.

Keywords: adolescents; cytomegalovirus; hematopoietic cell transplant; letermovir.

MeSH terms

  • Acetates* / therapeutic use
  • Adolescent
  • Antiviral Agents* / therapeutic use
  • Cytomegalovirus
  • Cytomegalovirus Infections* / drug therapy
  • Cytomegalovirus Infections* / prevention & control
  • Hematopoietic Stem Cell Transplantation* / adverse effects
  • Humans
  • Quinazolines* / therapeutic use

Substances

  • Acetates
  • Antiviral Agents
  • Quinazolines
  • letermovir