Assessment of Antibody and T-Cell Responses to the SARS-CoV-2 Virus and Omicron Variant in Unvaccinated Individuals Recovered From COVID-19 Infection in Wuhan, China

Li Guo; Qiao Zhang; Chongyang Zhang; Tingxuan Huang; Lili Ren; Bin Cao; Jianwei Wang

doi:10.1001/jamanetworkopen.2022.9199

Assessment of Antibody and T-Cell Responses to the SARS-CoV-2 Virus and Omicron Variant in Unvaccinated Individuals Recovered From COVID-19 Infection in Wuhan, China

JAMA Netw Open. 2022 Apr 1;5(4):e229199. doi: 10.1001/jamanetworkopen.2022.9199.

Authors

Li Guo¹, Qiao Zhang¹, Chongyang Zhang¹, Tingxuan Huang^{1

2}, Lili Ren¹, Bin Cao^{3

4}, Jianwei Wang¹

Affiliations

¹ National Health Commission Key Laboratory of Systems Biology of Pathogens and Christophe Mérieux Laboratory, Institute of Pathogen Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
² Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
³ Department of Pulmonary and Critical Care Medicine, National Center for Respiratory Medicine, Center of Respiratory Medicine, National Clinical Research Center for Respiratory Diseases, China-Japan Friendship Hospital, Beijing, China.
⁴ Institute of Respiratory Medicine, Chinese Academy of Medical Science, Beijing, China.

Abstract

This cohort study examines immune system responses to the Omicron strain of the SARS-CoV-2 virus among unvaccinated individuals in Wuhan, China, who recovered from infection with the initial strain of the virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

COVID-19*
Humans
SARS-CoV-2*
Spike Glycoprotein, Coronavirus
T-Lymphocytes

Substances

Spike Glycoprotein, Coronavirus
spike protein, SARS-CoV-2

Supplementary concepts

SARS-CoV-2 variants