The Interplay Between Nonalcoholic Fatty Liver Disease and Kidney Disease

Emily Truong; Mazen Noureddin

doi:10.1016/j.cld.2022.01.008

The Interplay Between Nonalcoholic Fatty Liver Disease and Kidney Disease

Clin Liver Dis. 2022 May;26(2):213-227. doi: 10.1016/j.cld.2022.01.008. Epub 2022 Apr 1.

Authors

Emily Truong¹, Mazen Noureddin²

Affiliations

¹ Department of Medicine, 8700 Beverly Boulevard, #5512, Los Angeles, CA 90048, USA; Cedars-Sinai Medical Center, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA.
² Department of Medicine, Karsh Division of Gastroenterology and Hepatology, Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA; Cedars-Sinai Fatty Liver Program, Division of Digestive and Liver Diseases, Department of Medicine, Comprehensive Transplant Center, Cedars-Sinai Medical Center, 8900 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address: [email protected].

PMID: 35487606
DOI: 10.1016/j.cld.2022.01.008

Abstract

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide, involving approximately 25% of the general population and increasing in prevalence in patient populations afflicted with metabolic syndrome and type 2 diabetes. This article discusses the complex interplay between NAFLD and chronic kidney disease (CKD), as well as the underlying pathogenesis and mechanisms through which NAFLD and CKD are linked. Exploration of these sophisticated relationships and causative factors is essential to accurately assessing kidney function in patients with NAFLD, recommending pharmacologic treatment of disease, and identifying favorable avenues for future investigation.

Keywords: Chronic kidney disease; Hepatocellular carcinoma; Nonalcoholic fatty liver disease; Type 2 diabetes mellitus.

Publication types

Review

MeSH terms

Diabetes Mellitus, Type 2* / complications
Diabetes Mellitus, Type 2* / epidemiology
Female
Humans
Male
Metabolic Syndrome* / complications
Metabolic Syndrome* / epidemiology
Non-alcoholic Fatty Liver Disease* / epidemiology
Prevalence
Renal Insufficiency, Chronic* / complications
Renal Insufficiency, Chronic* / epidemiology