Pronounced Orthostatic Hypotension in GBA-Related Parkinson's Disease

Tatiana Usnich; Henrike Hanssen; Katja Lohmann; Christina Lohse; Christine Klein; Meike Kasten; Norbert Brüggemann; EPIPARK Study Group

doi:10.3233/JPD-223197

Pronounced Orthostatic Hypotension in GBA-Related Parkinson's Disease

J Parkinsons Dis. 2022;12(5):1539-1544. doi: 10.3233/JPD-223197.

Authors

Tatiana Usnich¹, Henrike Hanssen^{1

2}, Katja Lohmann¹, Christina Lohse², Christine Klein¹, Meike Kasten^{1

3}, Norbert Brüggemann^{1

2}; EPIPARK Study Group

Affiliations

¹ Institute of Neurogenetics, University of Luebeck, Luebeck, Germany.
² Department of Neurology, University of Luebeck, Luebeck, Germany.
³ Department of Psychiatry and Psychotherapy, University of Luebeck, Luebeck, Germany.

PMID: 35491800
DOI: 10.3233/JPD-223197

Abstract

Patients with Parkinson's disease (PD) carrying variants in the Glucocerebrosidase (GBA) gene (GBA-PD) suffer from orthostatic symptoms more frequently than idiopathic PD patients (IPD). Systematic measurements of the blood pressure have not yet been performed. In the present study, a prospective analysis of 33 GBA-PD and 313 IPD patients was carried out. Systolic blood pressure upon changing from the supine to the upright position dropped more strongly in GBA-PD compared to IPD patients. Diastolic blood pressure and heart rate did not differ between groups. This study provides further evidence for a pronounced involvement of the autonomic nervous system in GBA-PD.

Keywords: Autonomic symptoms; GBA; Parkinson’s disease; orthostatic hypotension.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Autonomic Nervous System
Blood Pressure
Glucosylceramidase / genetics
Humans
Hypotension, Orthostatic* / etiology
Mutation
Parkinson Disease* / complications
Parkinson Disease* / diagnosis
Parkinson Disease* / genetics

Substances

Glucosylceramidase