Abstract
In the search for a new and better pertussis vaccine for general vaccination in Sweden, a clinical trial of an adsorbed acellular vaccine from Japan has been performed. The vaccine used was produced by Biken and contained only F-HA and the toxoid of pertussis toxin (LPF). The aims were: To demonstrate the serological response to primary vaccination of this adsorbed acellular vaccine in comparison to a plain whole cell vaccine. To compare the incidence of side reactions between the two types of vaccines and the adjuvant (aluminium phosphate) of the acellular vaccine used as placebo.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adjuvants, Immunologic / adverse effects
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Aluminum / adverse effects
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Aluminum Compounds*
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Antitoxins / analysis*
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Clinical Trials as Topic
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Double-Blind Method
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Humans
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Infant
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Pertussis Toxin*
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Pertussis Vaccine / adverse effects
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Pertussis Vaccine / immunology*
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Phosphates / adverse effects
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Random Allocation
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Vaccination
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Virulence Factors, Bordetella / immunology*
Substances
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Adjuvants, Immunologic
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Aluminum Compounds
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Antitoxins
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Pertussis Vaccine
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Phosphates
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Virulence Factors, Bordetella
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Aluminum
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Pertussis Toxin
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aluminum phosphate