Hybprinting for musculoskeletal tissue engineering

Jiannan Li; Carolyn Kim; Chi-Chun Pan; Aaron Babian; Elaine Lui; Jeffrey L Young; Seyedsina Moeinzadeh; Sungwoo Kim; Yunzhi Peter Yang

doi:10.1016/j.isci.2022.104229

Hybprinting for musculoskeletal tissue engineering

iScience. 2022 Apr 8;25(5):104229. doi: 10.1016/j.isci.2022.104229. eCollection 2022 May 20.

Authors

Jiannan Li¹, Carolyn Kim^{1

2}, Chi-Chun Pan^{1

2}, Aaron Babian³, Elaine Lui^{1

2}, Jeffrey L Young¹, Seyedsina Moeinzadeh¹, Sungwoo Kim¹, Yunzhi Peter Yang^{1

4

5}

Affiliations

¹ Department of Orthopaedic Surgery, School of Medicine, Stanford University, 300 Pasteur Drive BMI 258, Stanford, CA 94305, USA.
² Department of Mechanical Engineering, 416 Escondido Mall, Stanford University, Stanford, CA 94305, USA.
³ Department of Biological Sciences, University of California, Davis CA 95616, USA.
⁴ Department of Materials Science and Engineering, Stanford University, 496 Lomita Mall, Stanford, CA 94305, USA.
⁵ Department of Bioengineering, Stanford University, 443 Via Ortega, Stanford, CA 94305, USA.

Abstract

This review presents bioprinting methods, biomaterials, and printing strategies that may be used for composite tissue constructs for musculoskeletal applications. The printing methods discussed include those that are suitable for acellular and cellular components, and the biomaterials include soft and rigid components that are suitable for soft and/or hard tissues. We also present strategies that focus on the integration of cell-laden soft and acellular rigid components under a single printing platform. Given the structural and functional complexity of native musculoskeletal tissue, we envision that hybrid bioprinting, referred to as hybprinting, could provide unprecedented potential by combining different materials and bioprinting techniques to engineer and assemble modular tissues.

Keywords: Biotechnology; biomaterials; materials science; tissue engineering.

Publication types

Review