Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis

Maryam Mehdipour Dalivand; Parastou Tizro; Julie Partain; Anita Aggarwal; Jack Lichy; Francisco Mot Ara; Victor E Nava

doi:10.1155/2022/1132544

Concurrent B Cell Acute Lymphoblastic Lymphoma/Leukemia and Monoclonal B Cell Lymphocytosis: A Case Report with Extensive Molecular Analysis

Case Rep Hematol. 2022 Apr 21:2022:1132544. doi: 10.1155/2022/1132544. eCollection 2022.

Authors

Maryam Mehdipour Dalivand¹, Parastou Tizro¹, Julie Partain², Anita Aggarwal^{3

4}, Jack Lichy^{1

5}, Francisco Mot Ara⁶, Victor E Nava^{1

5

6}

Affiliations

¹ The George Washington University, Department of Pathology, Washington, DC, USA.
² Oregon Health and Science University, Portland, OR, USA.
³ The George Washington University, Department of Medicine, Hematology and Oncology, Washington, DC, USA.
⁴ Veterans Health Administration, Department of Internal Medicine, Oncology and Hematology, Washington, DC, USA.
⁵ Veterans Health Administration, Department of Pathology, Washington, DC, USA.
⁶ Hospital J.M. de Los Rios, Department of Pathology, Caracas, Venezuela.

Abstract

Although acute lymphoblastic leukemia (ALL) and monoclonal B cell lymphocytosis (MBL) are common neoplasia, a simultaneous presentation is very unusual. Here, we present two different B cell clones, MBL and B-ALL, cocirculating in a 78-year-old African American male. Detailed molecular characterization revealed an unusual MPL (T487I) point mutation and unmutated VH4-39. After nonstandard chemotherapy, the patient remains in morphologic remission. These findings may stimulate further research to clarify the pathogenesis of hematologic neoplasms.

Publication types

Case Reports