A mysterious case of recurrent fracture: Tumour-induced osteomalacia

Sahana Shetty; Shruthi Ravindra; Himamshu Acharya; Sharath K Rao

doi:10.4103/jfmpc.jfmpc_947_21

A mysterious case of recurrent fracture: Tumour-induced osteomalacia

J Family Med Prim Care. 2022 Mar;11(3):1204-1207. doi: 10.4103/jfmpc.jfmpc_947_21. Epub 2022 Mar 10.

Authors

Sahana Shetty¹, Shruthi Ravindra¹, Himamshu Acharya¹, Sharath K Rao²

Affiliations

¹ Department of Endocrinology, Kasturba Medical College, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, India.
² Department of Orthopaedics, Kasturba Medical College, Manipal Academy of Higher Education, MAHE, Manipal, Karnataka, India.

Abstract

We report a case of tumour-induced osteomalacia in a 59-year-old man who presented with a long-standing history of myalgia, bone pain and pathological fracture of the bilateral femur at different intervals in the past 4 years. A biochemical evaluation revealed hypophosphatemia secondary to phosphaturia. Localization study by Ga-68 DOTANOC PET-CT for adult-onset hypophosphatemic osteomalacia revealed a tumour in the right femoral head. Resection of the tumour resulted in clinical improvement as well as normalization of biochemical parameters.

Keywords: FGF-23; hypophosphatemia; tumour-induced osteomalacia.

Publication types

Case Reports