Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

Ying Ma; Haigang Tian; Zhengyu Jin; Xiaoyong Li; Yiping Li

doi:10.1039/c8ra10053e

Observation of the generation of peroxynitrite in mouse liver after acetaminophen overdose with a boronate-based ratiometric fluorescence probe

RSC Adv. 2019 Feb 25;9(12):6510-6514. doi: 10.1039/c8ra10053e. eCollection 2019 Feb 22.

Authors

Ying Ma¹, Haigang Tian¹, Zhengyu Jin¹, Xiaoyong Li², Yiping Li¹

Affiliations

¹ School of Pharmacy, Health Science Center, Xi'an Jiaotong University Xi'an 710061 Shaanxi China [email protected].
² School of Science, Xi'an Jiaotong University Xi'an 710061 Shaanxi China [email protected].

Abstract

A ratiometric fluorescent probe, BTPB, for the selective monitoring of hepatic peroxynitrite (ONOO^-) in situ after acetaminophen (APAP) overdose has been developed. Our study provided direct evidence for supporting the generation of ONOO^- in APAP-induced liver injury. This new probe will be a useful tool for studying the roles of ONOO^- in vivo.