Death by differentiation: CD4+ T cells kick out suspicious stem cells

Sara Tomei; Cindy Audiger; Shalin H Naik

doi:10.1016/j.stem.2022.04.013

Death by differentiation: CD4⁺ T cells kick out suspicious stem cells

Cell Stem Cell. 2022 May 5;29(5):655-656. doi: 10.1016/j.stem.2022.04.013.

Authors

Sara Tomei¹, Cindy Audiger¹, Shalin H Naik²

Affiliations

¹ Immunology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia.
² Immunology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia. Electronic address: [email protected].

PMID: 35523132
DOI: 10.1016/j.stem.2022.04.013

Abstract

Antigen presentation is typically regarded as the domain of immune cells such as dendritic cells and B cells. Hernandez-Malmierca et al. (2022) upend this notion by observing that hematopoietic stem and progenitor cells process and present antigen via major histocompatibility class II as a means of CD4⁺ T cell-mediated immune surveillance.

Publication types

Comment

MeSH terms

Antigen Presentation
B-Lymphocytes
CD4-Positive T-Lymphocytes*
Dendritic Cells
Histocompatibility Antigens Class II*
Stem Cells

Substances

Histocompatibility Antigens Class II