Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence

Yuan Liu; Liping Huang; Yi Zeng; Mingyang Li; Huiqi Xie; Bin Shen

doi:10.1007/s11427-021-2090-3

Intra-articular injection of stromal vascular fraction for knee degenerative joint disease: a concise review of preclinical and clinical evidence

Sci China Life Sci. 2022 Oct;65(10):1959-1970. doi: 10.1007/s11427-021-2090-3. Epub 2022 May 5.

Authors

Yuan Liu^#^{1

2}, Liping Huang^#², Yi Zeng¹, Mingyang Li¹, Huiqi Xie³, Bin Shen⁴

Affiliations

¹ Orthopedics Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
² Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
³ Laboratory of Stem Cell and Tissue Engineering, Orthopedic Research Institute, Med-X Center for Materials, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. [email protected].
⁴ Orthopedics Research Institute, Department of Orthopedics, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China. [email protected].

^# Contributed equally.

PMID: 35524910
DOI: 10.1007/s11427-021-2090-3

Abstract

Autologous fat-derived stromal vascular fraction (SVF) is a mixed cell population that has been used for many years in regenerative plastic surgery. In terms of animal and clinical research, this concise review was performed to evaluate the efficacy of SVF in knee degenerative joint disease (KDJD), which could cause pain, disability and severely affect patients' lives. Thirteen studies retrieved and screened from the databases were included, including six animal studies and seven clinical trials. The meta-analysis of clinical research shows that intra-articular injection of SVF, in combination with adjuvant surgery, could alleviate pain and improve early functional recovery for patients with KDJD at Kellgren-Lawrence (KL) grades II-III.

Keywords: knee degenerative joint disease; meta-analysis; review; stromal vascular fraction.

Publication types

Meta-Analysis
Review

MeSH terms

Animals
Injections, Intra-Articular
Osteoarthritis, Knee* / surgery
Stromal Vascular Fraction*
Treatment Outcome