Findings, limitations and new directions in tACS studies in schizophrenia research: A scoping review

Background: Schizophrenia (SZ) is a severe neurodevelopmental spectrum disorder with significant consequences for the individual who is diagnosed and their family, resulting in notable system-level costs associated with the current methods of treatment. With a complex etiology, this syndrome continues to evade our thorough understanding and invites cautious analysis into how the newest research findings may translate into meaningful interventions. Recent explorations of non-invasive interventions in psychiatry suggest that transcranial alternating current stimulation (tACS) is a safe and potentially promising add-on to the current SZ treatment.

Methods: We performed a systematic literature search for tACS studies on SZ in three databases - Embase, Pubmed and Medline. The search yielded 29 titles and abstracts, of which 8 met the criteria for inclusion: experimental use of tACS on patients with SZ.

Results: We found 8 publications where findings from tACS were applied on participants with SZ. The most common frequencies used were theta (4.5 Hertz [Hz] and 6 Hz), alpha (10 Hz) and gamma (40 Hz). The main findings resulting from tACS delivery were: (1) decrease in auditory hallucinations; (2) decrease in negative symptoms; (3) cognitive improvement; and, (4) no change.

Conclusions: This scoping review provides a highlight of current protocols used in tACS studies on SZ, their main findings and limitations, and points towards a direction for new approaches. The wide variety of objectives, protocols and assessments used by researchers demonstrates the diversified nature of research currently used in this field, suggesting the need for a more thorough exploration as results continue to emerge.