Local Therapies in Advanced Colorectal Cancer

Hematol Oncol Clin North Am. 2022 Jun;36(3):553-567. doi: 10.1016/j.hoc.2022.02.007. Epub 2022 May 11.

Abstract

Curative intent surgical resection of colorectal metastases to the liver and lungs in eligible patients results in improved disease control and prolonged overall survival with the potential for cure in a subset of patients. Additional ablative and local therapies for use in the liver, lungs, and other body sites have been developed with emerging data on the utility and toxicity of these treatments. Future studies should focus on identification of appropriate candidates for treatment and determining the optimal modality and timing of treatment accounting for both patient and disease factors.

Keywords: Ablative therapy; Colorectal cancer; Local therapy; Metastatic; Stereotactic ablative radiotherapy; Surgery.

Publication types

  • Review
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Colorectal Neoplasms* / pathology
  • Colorectal Neoplasms* / therapy
  • Humans
  • Liver Neoplasms* / secondary
  • Liver Neoplasms* / surgery