Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles

Yasuhiro Nakagawa; Jeonggyu Lee; Yihua Liu; Saed Abbasi; Taehun Hong; Horacio Cabral; Satoshi Uchida; Mitsuhiro Ebara

doi:10.1021/acsmacrolett.1c00643

Microglial Immunoregulation by Apoptotic Cellular Membrane Mimetic Polymeric Particles

ACS Macro Lett. 2022 Feb 15;11(2):270-275. doi: 10.1021/acsmacrolett.1c00643. Epub 2022 Jan 28.

Authors

Yasuhiro Nakagawa^{1

2

3

4

5}, Jeonggyu Lee^{4

5}, Yihua Liu⁴, Saed Abbasi², Taehun Hong^{2

3}, Horacio Cabral^{2

3}, Satoshi Uchida^{2

3

6}, Mitsuhiro Ebara^{4

5

7}

Affiliations

¹ School of Materials and Chemical Technology, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8550, Japan.
² Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14, Tonomachi, Kawasaki-ku, Kanagawa 210-0821, Japan.
³ Graduate School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
⁴ Research Center for Functional Materials, National Institute for Materials Science (NIMS), 1-1, Namiki, Tsukuba, Ibaraki 305-0044, Japan.
⁵ Graduate School of Pure and Applied Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan.
⁶ Graduate School of Medicine, Kyoto Prefectural University of Medicine, 1-5, Shimogamohangi-cho, Sakyo-ku, Kyoto 606-0823, Japan.
⁷ Graduate School of Advanced Engineering, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 162-8601, Japan.

PMID: 35574780
DOI: 10.1021/acsmacrolett.1c00643

Abstract

Phosphatidylserine (PtdSer), one of the phospholipids that the apoptotic cell exposes, has emerged for anti-inflammatory therapy via polarizing inflammatory microglia (Mi1) to anti-inflammatory phenotype (Mi2). In this study, we report microglia polarization effect of PtdSer-exposing polymeric particles (PSPs). PSPs upregulated Mi2 microglia and suppressed Mi1 microglia through peroxisome proliferator-activated receptor gamma upregulation in vitro and in vivo. This study highlights the potential of PSPs for anti-inflammatory therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Inflammatory Agents / pharmacology
Microglia*
PPAR gamma* / genetics
Phosphatidylserines / pharmacology

Substances

Anti-Inflammatory Agents
PPAR gamma
Phosphatidylserines