Treatment and secondary prophylaxis of venous thromboembolism in cancer patients

Support Care Cancer. 2022 Oct;30(10):8519-8526. doi: 10.1007/s00520-022-07135-x. Epub 2022 May 19.

Abstract

Cancer-associated thrombosis (CAT) adversely affects the quality of life and survival of people with cancer. A holistic approach is optimal for the treatment and secondary prophylaxis of venous thromboembolism (VTE) including shared decision-making around anticoagulation, considering individual risk factors for VTE recurrence, morbidities from VTE, and resources available in cancer centres around the world. Taking a global perspective on availability and cost, this paper guides the reader through the wider aspects of treatment and secondary thromboprophylaxis which, in turn, influence the recent international guidelines.

Keywords: Cancer-associated thrombosis; Direct oral anticoagulant; Low-molecular-weight heparin; Treatment and secondary thromboprophylaxis.

MeSH terms

  • Anticoagulants / therapeutic use
  • Heparin, Low-Molecular-Weight / therapeutic use
  • Humans
  • Neoplasms* / complications
  • Neoplasms* / drug therapy
  • Quality of Life
  • Secondary Prevention
  • Venous Thromboembolism* / drug therapy
  • Venous Thromboembolism* / etiology
  • Venous Thromboembolism* / prevention & control

Substances

  • Anticoagulants
  • Heparin, Low-Molecular-Weight