Why you always in a mood? Pumpin' polyP, actin' brand new

Kevin A Guttenplan; Aaron D Gitler

doi:10.1016/j.neuron.2022.04.003

Why you always in a mood? Pumpin' polyP, actin' brand new

Neuron. 2022 May 18;110(10):1603-1605. doi: 10.1016/j.neuron.2022.04.003.

Authors

Kevin A Guttenplan¹, Aaron D Gitler²

Affiliations

¹ Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA; Vollum Institute, Oregon Health and Science University, Portland, OR 97239, USA.
² Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: [email protected].

PMID: 35588711
DOI: 10.1016/j.neuron.2022.04.003

Abstract

What causes neurons to die in neurodegenerative disease? In this issue of Neuron, Arredondo et al., 2022 report an unexpected culprit that may drive neuronal death in amyotrophic lateral sclerosis-an evolutionarily ancient energy-storage polymer called polyphosphate (polyP).

Publication types

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MeSH terms

Actins
Amyotrophic Lateral Sclerosis*
Cell Death
Humans
Neurodegenerative Diseases*
Neurons

Substances

Actins