"Beyond MELD" - Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation

Jin Ge; W Ray Kim; Jennifer C Lai; Allison J Kwong

doi:10.1016/j.jhep.2022.03.003

"Beyond MELD" - Emerging strategies and technologies for improving mortality prediction, organ allocation and outcomes in liver transplantation

J Hepatol. 2022 Jun;76(6):1318-1329. doi: 10.1016/j.jhep.2022.03.003.

Authors

Jin Ge¹, W Ray Kim², Jennifer C Lai¹, Allison J Kwong³

Affiliations

¹ Division of Gastroenterology and Hepatology, Department of Medicine, University of California - San Francisco, San Francisco, CA, USA.
² Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: [email protected].
³ Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Abstract

In this review article, we discuss the model for end-stage liver disease (MELD) score and its dual purpose in general and transplant hepatology. As the landscape of liver disease and transplantation has evolved considerably since the advent of the MELD score, we summarise emerging concepts, methodologies, and technologies that may improve mortality prognostication in the future. Finally, we explore how these novel concepts and technologies may be incorporated into clinical practice.

Keywords: Allocation; Clinical Decision Support; EHR; Frailty; MELD; OMOP; Prognostication; Sarcopenia.

Publication types

Review
Research Support, N.I.H., Extramural

MeSH terms

End Stage Liver Disease* / surgery
Humans
Liver Transplantation*
Severity of Illness Index
Tissue and Organ Procurement*
Waiting Lists

Abstract

Publication types

MeSH terms

Grants and funding