Pathways from Immune Profiling to Therapies for Rare Diseases

Averil Ma

doi:10.1016/j.medj.2020.12.014

Pathways from Immune Profiling to Therapies for Rare Diseases

Med. 2021 Jan 15;2(1):14-15. doi: 10.1016/j.medj.2020.12.014.

Author

Averil Ma¹

Affiliation

¹ Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: [email protected].

PMID: 35590128
DOI: 10.1016/j.medj.2020.12.014

Abstract

Single-cell transcriptomic profiling has enhanced the description of several diseases. Beyond improving our understanding of the pathophysiology of these diseases, these approaches can lead to clues about therapeutic approaches. In a recent issue of Cell, Wang et al. describe immune perturbations in livers of biliary atresia patients that implicate specific autoimmune pathways of disease.¹.

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MeSH terms

Biliary Atresia* / metabolism
Gene Expression Profiling
Humans
Liver / metabolism
Rare Diseases* / genetics