The peripheral nervous system and the immune system are virtually distributed in all organs in mouse and human. They act in concert to constitute an exceptional sensory system capable of sensing threatening stimuli, including allergens, and triggering appropriate biological responses. Recent advances in the field have revealed that tissue-resident mast cells and nearby sensory neurons could form functional neuroimmune clusters driven by bidirectional interactions and predisposed to significantly influence major allergic conditions. In this review, we highlight recent discoveries that paved the way toward a better understanding of how mast cells and sensory neurons can communicate to regulate basic features of allergic disorders in different organs.
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