Relationship between epithelial organization and morphogen interpretation

Dagmar Iber; Roman Vetter

doi:10.1016/j.gde.2022.101916

Relationship between epithelial organization and morphogen interpretation

Curr Opin Genet Dev. 2022 Aug:75:101916. doi: 10.1016/j.gde.2022.101916. Epub 2022 May 20.

Authors

Dagmar Iber¹, Roman Vetter²

Affiliations

¹ Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland; Swiss Institute of Bioinformatics, Mattenstrasse 26, 4058 Basel, Switzerland. Electronic address: [email protected].
² Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, 4058 Basel, Switzerland; Swiss Institute of Bioinformatics, Mattenstrasse 26, 4058 Basel, Switzerland.

PMID: 35605527
DOI: 10.1016/j.gde.2022.101916

Abstract

Despite molecular noise and genetic differences between individuals, developmental outcomes are remarkably constant. Decades of research has focused on the underlying mechanisms that ensure this precision and robustness. Recent quantifications of chemical gradients and epithelial cell shapes provide novel insights into the basis of precise development. In this review, we argue that these two aspects may be linked in epithelial morphogenesis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Body Patterning*
Gene Expression Regulation, Developmental / genetics
Humans
Models, Biological*
Morphogenesis / genetics
Signal Transduction / genetics