Long non-coding RNAs in virus-related cancers

Yushan Huang; Longchang Jiang; Yang Liu; Lixian Liu; Junling Wang; Lei Shi

doi:10.1002/rmv.2364

Long non-coding RNAs in virus-related cancers

Rev Med Virol. 2022 Nov;32(6):e2364. doi: 10.1002/rmv.2364. Epub 2022 May 24.

Authors

Yushan Huang¹, Longchang Jiang^{2

3}, Yang Liu⁴, Lixian Liu⁵, Junling Wang¹, Lei Shi¹

Affiliations

¹ School of Public Health, Lanzhou University, Lanzhou, China.
² Department of Vascular Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
³ Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
⁴ Gansu Provincial People's Hospital, Lanzhou, China.
⁵ Shijiangzhuang City Zoo, Shijiazhuang, China.

PMID: 35607835
DOI: 10.1002/rmv.2364

Abstract

Some viral infections lead to tumourigenesis explained by a variety of underlying molecular mechanisms. Long non-coding RNAs (lncRNAs) have the potential to be added to this list due to their diverse mechanisms in biological functions and disease processes via gene alternation, transcriptional regulation, protein modification, microRNA sponging and interaction with RNA/DNA/proteins. In this review, we summarise the dysregulation and mechanism of lncRNAs in virus-related cancers focussing on Hepatitis B virus, Epstein-Barr virus, Human Papillomavirus. We will also discuss the potential implications of lncRNAs in COVID-19.

Keywords: Cancer; LncRNA; SARS-CoV-2; Virus.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

COVID-19 / genetics
Epstein-Barr Virus Infections* / complications
Epstein-Barr Virus Infections* / genetics
Hepatitis B* / complications
Hepatitis B* / genetics
Humans
Neoplasms* / genetics
Neoplasms* / virology
Papillomavirus Infections* / complications
RNA, Long Noncoding* / genetics

Substances

RNA, Long Noncoding